JEAN-FRAN?OIS PAQUIN studied chemistry at Université Laval(Quebec City, Canada)where he graduated with a B.Sc. degree in 1999. In 2004, he received his Ph.D. degree at the University of Toronto (Canada). After a postdoctoral stay at the ETH Zürich (Switzerland), he was appointed assistant professor in 2005 at Université Laval (Quebec City, Canada) as a Tier 2 Canada Research Chair in Organic and Medicinal Chemistry (2005-2010). In 2010, he was promoted to associate professor and his Canada Research Chair in Organic and Medicinal Chemistry renewed (2010-2015). He was promoted to Full Professor in 2014. He has been awarded, in 2015, a Humboldt Research Fellowship for a 6-month stay at the KIT in the group of Professor Anne S. Ulrich (Karlsruhe, Germany). In 2016, he received the Keith Fagnou Award from the Canadian Society of Chemistry. His research interests include the development of novel methodologies for the synthesis of organofluorine compounds and their applications for the preparation of bioactive fluorinated compounds or fluorinated biological probes. Jean-Fran?ois has co-authored more than one hundred publications in addition to fifteen book chapters. He has presented more than one hundred invited lectures. Jean-Fran?ois is a member of the Canadian Society for Chemistry (CSC) and the American Chemical Society (ACS). He has been a member-at-large on the executive committee of the Fluorine Chemistry Division of the ACS from 2013 to 2022. Finally, he was one of the co-hosts for the International Symposium on Fluorine Chemistry that took place in Quebec City in July 2023.
This talk will introduce our recent advances in the chemistry of the pentafluorosulfanyl group, including Light-activation of SF5Cl for the atom transfer radical addition onto alkenes and alkynes, and Photoinitiated anti-Hydropentafluorosulfanylation of Terminal Alkynes to access SF5-containing alkanes or alkenes, the synthesis of aliphatic SF5-containing compounds using the Kolbe reaction, as well as Rhodium-Catalyzed Intramolecular Cyclopropanation of Pentafluorosulfanyl-Substituted Allylic Cyanodiazoacetates to prepare SF5-substituted cyclopropane, etc. Finally, these new processes are then use to synthesize bioactives molecules or compound with therapeutic interestin.
